ACT1/YFL039C Gene Ontology Annotations

This page displays GO annotations in different sections according to the annotation method used to add that annotation to SGD.

ACT1 Manually curated*:

Jump to: top | High-throughput | Computational

Last Reviewed on: 2005-02-01 Molecular Function | Biological Process | Cellular Component

Manually curated Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
structural constituent of cytoskeleton	TAS: Traceable Author Statement Assigned on 2001-01-19	Botstein D, et al. (1997) "The yeast cytoskeleton." Pp. 1-90 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Cell Cycle and Cell Biology, edited by Pringle JR, Broach JR and Jones EW. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press	SGD

Manually curated Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
actin filament reorganization during cell cycle	TAS: Traceable Author Statement Assigned on 2001-12-17	Botstein D, et al. (1997) "The yeast cytoskeleton." Pp. 1-90 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Cell Cycle and Cell Biology, edited by Pringle JR, Broach JR and Jones EW. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press	SGD
ascospore wall assembly	IDA: Inferred from Direct Assay Assigned on 2008-12-01	Taxis C, et al. (2006) Dynamic Organization of the Actin Cytoskeleton During Meiosis and Spore Formation in Budding Yeast. Traffic 7(12):1628-1642	SGD
budding cell isotropic bud growth	TAS: Traceable Author Statement Assigned on 2004-10-01	Pruyne D and Bretscher A (2000) Polarization of cell growth in yeast. J Cell Sci 113 ( Pt 4):571-85	SGD
cell wall organization	TAS: Traceable Author Statement Assigned on 2001-01-18	Pruyne D and Bretscher A (2000) Polarization of cell growth in yeast. J Cell Sci 113 ( Pt 4):571-85	SGD
chronological cell aging	IMP: Inferred from Mutant Phenotype Assigned on 2004-10-01	Gourlay CW, et al. (2004) A role for the actin cytoskeleton in cell death and aging in yeast. J Cell Biol 164(6):803-9	SGD
contractile ring contraction involved in cytokinesis during cell cycle	IDA: Inferred from Direct Assay Assigned on 2006-09-19	Bi E, et al. (1998) Involvement of an actomyosin contractile ring in Saccharomyces cerevisiae cytokinesis. J Cell Biol 142(5):1301-12	SGD
cytokinesis	IDA: Inferred from Direct Assay Assigned on 2006-09-18	Bi E, et al. (1998) Involvement of an actomyosin contractile ring in Saccharomyces cerevisiae cytokinesis. J Cell Biol 142(5):1301-12	SGD
DNA repair	IDA: Inferred from Direct Assay Assigned on 2007-01-03	Utley RT, et al. (2005) Regulation of NuA4 histone acetyltransferase activity in transcription and DNA repair by phosphorylation of histone H4. Mol Cell Biol 25(18):8179-90	SGD
endocytosis	IMP: Inferred from Mutant Phenotype Assigned on 2009-03-11	Munn AL, et al. (1995) end5, end6, and end7: mutations that cause actin delocalization and block the internalization step of endocytosis in Saccharomyces cerevisiae. Mol Biol Cell 6(12):1721-42	SGD
establishment of cell polarity	TAS: Traceable Author Statement Assigned on 2001-03-02	Botstein D, et al. (1997) "The yeast cytoskeleton." Pp. 1-90 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Cell Cycle and Cell Biology, edited by Pringle JR, Broach JR and Jones EW. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press	SGD
establishment of mitotic spindle orientation	TAS: Traceable Author Statement Assigned on 2004-01-28	Pruyne D and Bretscher A (2000) Polarization of cell growth in yeast. J Cell Sci 113 ( Pt 4):571-85	SGD
exocytosis	TAS: Traceable Author Statement Assigned on 2001-01-18	Pruyne D and Bretscher A (2000) Polarization of cell growth in yeast. J Cell Sci 113 ( Pt 4):571-85	SGD
histone acetylation	IDA: Inferred from Direct Assay Assigned on 2002-09-18	Galarneau L, et al. (2000) Multiple links between the NuA4 histone acetyltransferase complex and epigenetic control of transcription. Mol Cell 5(6):927-37	SGD
mitochondrion inheritance	TAS: Traceable Author Statement Assigned on 2001-01-18	Pruyne D and Bretscher A (2000) Polarization of cell growth in yeast. J Cell Sci 113 ( Pt 4):571-85	SGD
protein secretion	TAS: Traceable Author Statement Assigned on 2001-12-17	Botstein D, et al. (1997) "The yeast cytoskeleton." Pp. 1-90 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Cell Cycle and Cell Biology, edited by Pringle JR, Broach JR and Jones EW. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press	SGD
regulation of transcription from RNA polymerase II promoter	IDA: Inferred from Direct Assay Assigned on 2002-09-18	Galarneau L, et al. (2000) Multiple links between the NuA4 histone acetyltransferase complex and epigenetic control of transcription. Mol Cell 5(6):927-37	SGD
response to oxidative stress	IGI: Inferred from Genetic Interaction with SGD:OYE2 Assigned on 2007-02-12	Farah ME and Amberg DC (2007) Conserved actin cysteine residues are oxidative stress sensors that can regulate cell death in yeast. Mol Biol Cell 18(4):1359-65	SGD
vacuole inheritance	IGI: Inferred from Genetic Interaction Assigned on 2006-10-19 IMP: Inferred from Mutant Phenotype Assigned on 2006-10-19	Hill KL, et al. (1996) Actin and myosin function in directed vacuole movement during cell division in Saccharomyces cerevisiae. J Cell Biol 135(6 Pt 1):1535-49	SGD
vesicle transport along actin filament	TAS: Traceable Author Statement Assigned on 2001-12-17	Pruyne D and Bretscher A (2000) Polarization of cell growth in yeast. J Cell Sci 113 ( Pt 4):571-85	SGD

Manually curated Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
actin cortical patch	IDA: Inferred from Direct Assay Assigned on 2009-11-11	Mulholland J, et al. (1994) Ultrastructure of the yeast actin cytoskeleton and its association with the plasma membrane. J Cell Biol 125(2):381-91	SGD
	IDA: Inferred from Direct Assay Assigned on 2009-11-11	Novick P and Botstein D (1985) Phenotypic analysis of temperature-sensitive yeast actin mutants. Cell 40(2):405-16	SGD
	IDA: Inferred from Direct Assay Assigned on 2009-11-11	Kilmartin JV and Adams AE (1984) Structural rearrangements of tubulin and actin during the cell cycle of the yeast Saccharomyces. J Cell Biol 98(3):922-33	SGD
actin filament	TAS: Traceable Author Statement Assigned on 2001-01-19	Botstein D, et al. (1997) "The yeast cytoskeleton." Pp. 1-90 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Cell Cycle and Cell Biology, edited by Pringle JR, Broach JR and Jones EW. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press	SGD
actin filament bundle	IDA: Inferred from Direct Assay Assigned on 2009-11-11	Mulholland J, et al. (1994) Ultrastructure of the yeast actin cytoskeleton and its association with the plasma membrane. J Cell Biol 125(2):381-91	SGD
	IDA: Inferred from Direct Assay Assigned on 2009-11-11	Novick P and Botstein D (1985) Phenotypic analysis of temperature-sensitive yeast actin mutants. Cell 40(2):405-16	SGD
	IDA: Inferred from Direct Assay Assigned on 2009-11-11	Kilmartin JV and Adams AE (1984) Structural rearrangements of tubulin and actin during the cell cycle of the yeast Saccharomyces. J Cell Biol 98(3):922-33	SGD
cellular bud neck contractile ring	IDA: Inferred from Direct Assay Assigned on 2009-11-11	Mulholland J, et al. (1994) Ultrastructure of the yeast actin cytoskeleton and its association with the plasma membrane. J Cell Biol 125(2):381-91	SGD
cellular bud neck contractile ring	IDA: Inferred from Direct Assay Assigned on 2009-11-11	Novick P and Botstein D (1985) Phenotypic analysis of temperature-sensitive yeast actin mutants. Cell 40(2):405-16	SGD
histone acetyltransferase complex	IDA: Inferred from Direct Assay Assigned on 2002-09-18	Galarneau L, et al. (2000) Multiple links between the NuA4 histone acetyltransferase complex and epigenetic control of transcription. Mol Cell 5(6):927-37	SGD
Ino80 complex	IPI: Inferred from Physical Interaction with SGD:INO80 Assigned on 2005-04-11	Shen X, et al. (2000) A chromatin remodelling complex involved in transcription and DNA processing. Nature 406(6795):541-4	SGD
NuA4 histone acetyltransferase complex	IPI: Inferred from Physical Interaction Assigned on 2007-01-03	Zhang H, et al. (2004) The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres. Mol Cell Biol 24(21):9424-36	SGD
Swr1 complex	IDA: Inferred from Direct Assay Assigned on 2004-04-12	Krogan NJ, et al. (2003) A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell 12(6):1565-76	SGD
	IDA: Inferred from Direct Assay Assigned on 2006-10-24	Wu WH, et al. (2005) Swc2 is a widely conserved H2AZ-binding module essential for ATP-dependent histone exchange. Nat Struct Mol Biol 12(12):1064-71	SGD
	IDA: Inferred from Direct Assay Assigned on 2004-04-12	Mizuguchi G, et al. (2004) ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science 303(5656):343-8	SGD

* Manually curated GO annotations reflect our best understanding of the basic molecular function, biological process, and cellular component for this gene product. Manually curated annotations are assigned by SGD curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all Manually curated GO annotations for accuracy and completeness. The "Last Reviewed on:" date at the top of this section indicates when these annotations were last reviewed.

ACT1 High-throughput**:

Jump to: top | Manually curated | Computational

There are no High-throughput annotations for ACT1

** GO annotations from High-throughput experiments are made based on a variety of large scale high-throughput experiments, including genome-wide experiments. Many of these annotations are made based on GO annotations (or mappings to GO annotations) assigned by the authors, rather than SGD curators. While SGD curators read these publications and often work closely with authors to incorporate the information, each individual annotation may not necessarily be reviewed by a curator. GO Annotations from high-throughput experiments will be assigned only when this type of data is available, and thus may not be assigned in all three aspects of the Gene Ontologies.

ACT1 Computational***:

Jump to: top | Manually curated | High-throughput

Molecular Function | Biological Process | Cellular Component

Computational Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
3'-5' DNA helicase activity	RCA: Reviewed Computational Analysis Last updated 2009-09-03	Tian W, et al. (2008) Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1:S7	YeastFunc
acid-amino acid ligase activity	RCA: Reviewed Computational Analysis Last updated 2009-09-03	Tian W, et al. (2008) Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1:S7	YeastFunc
ATP binding	IEA: Inferred from Electronic Annotation with EBI:IPR004001 Last updated 2009-10-01	DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms.	UniProtKB
ATP binding	IEA: Inferred from Electronic Annotation with EBI:KW-0067 Last updated 2009-10-01	GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping.	UniProtKB
ATP-dependent 3'-5' DNA helicase activity	RCA: Reviewed Computational Analysis Last updated 2009-09-03	Tian W, et al. (2008) Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1:S7	YeastFunc
ATP-dependent DNA helicase activity	RCA: Reviewed Computational Analysis Last updated 2009-09-03	Tian W, et al. (2008) Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1:S7	YeastFunc
ATP-dependent helicase activity	RCA: Reviewed Computational Analysis Last updated 2009-09-03	Tian W, et al. (2008) Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1:S7	YeastFunc
ATPase activity	RCA: Reviewed Computational Analysis Last updated 2009-09-03	Tian W, et al. (2008) Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1:S7	YeastFunc
ATPase activity, coupled	RCA: Reviewed Computational Analysis Last updated 2009-09-03	Tian W, et al. (2008) Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1:S7	YeastFunc
chromatin binding	RCA: Reviewed Computational Analysis Last updated 2009-09-03	Tian W, et al. (2008) Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1:S7	YeastFunc
DNA helicase activity	RCA: Reviewed Computational Analysis Last updated 2009-09-03	Tian W, et al. (2008) Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1:S7	YeastFunc
DNA-dependent ATPase activity	RCA: Reviewed Computational Analysis Last updated 2009-09-03	Tian W, et al. (2008) Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1:S7	YeastFunc
helicase activity	RCA: Reviewed Computational Analysis Last updated 2009-09-03	Tian W, et al. (2008) Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1:S7	YeastFunc
histone acetyltransferase activity	RCA: Reviewed Computational Analysis Last updated 2009-09-03	Tian W, et al. (2008) Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1:S7	YeastFunc
ligase activity	RCA: Reviewed Computational Analysis Last updated 2009-09-03	Tian W, et al. (2008) Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1:S7	YeastFunc
ligase activity, forming carbon-nitrogen bonds	RCA: Reviewed Computational Analysis Last updated 2009-09-03	Tian W, et al. (2008) Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1:S7	YeastFunc
lysine N-acetyltransferase activity	RCA: Reviewed Computational Analysis Last updated 2009-09-03	Tian W, et al. (2008) Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1:S7	YeastFunc
nucleotide binding	IEA: Inferred from Electronic Annotation with EBI:KW-0547 Last updated 2009-10-01	GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping.	UniProtKB
purine NTP-dependent helicase activity	RCA: Reviewed Computational Analysis Last updated 2009-09-03	Tian W, et al. (2008) Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1:S7	YeastFunc
small conjugating protein ligase activity	RCA: Reviewed Computational Analysis Last updated 2009-09-03	Tian W, et al. (2008) Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1:S7	YeastFunc
transferase activity, transferring acyl groups	RCA: Reviewed Computational Analysis Last updated 2009-09-03	Tian W, et al. (2008) Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1:S7	YeastFunc
ubiquitin-protein ligase activity	RCA: Reviewed Computational Analysis Last updated 2009-09-03	Tian W, et al. (2008) Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1:S7	YeastFunc

Computational Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
chromatin remodeling	RCA: Reviewed Computational Analysis Last updated 2009-09-03	Tian W, et al. (2008) Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1:S7	YeastFunc
regulation of transport	RCA: Reviewed Computational Analysis Last updated 2009-08-06	Huttenhower C and Troyanskaya OG (2009) Prediction of Gene Ontology annotations by integrating high-throughput datasets	bioPIXIE_MEFIT

Computational Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
cytoplasm	IEA: Inferred from Electronic Annotation with EBI:KW-0963 Last updated 2009-10-01	GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping.	UniProtKB
cytoskeleton	IEA: Inferred from Electronic Annotation with EBI:SL-0090 Last updated 2009-10-01	GOA curators and UniProt curators (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping.	UniProtKB
cytoskeleton	IEA: Inferred from Electronic Annotation with EBI:KW-0206 Last updated 2009-10-01	GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping.	UniProtKB

*** Computational GO Annotations are predictions. These annotations are NOT reviewed by a curator. Currently, all computational GO annotations for S. cerevisiae are assigned by an external source (for example, the Gene Ontology Annotation (GOA) project of the European Bioinformatics Institute (EBI)).

SGD^tm pages Database Copyright © 1997-2008 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.